University of agribusiness and rural development, UARD Jubilee International Scientific Conference

Font Size: 
The Processing of Pufferfish and Usage of Tetrodotoxin in the Pharmaceutical Industry
Nermin Berik, Ekrem Cankiriligil

Last modified: 2018-02-12

Abstract


The pufferfish is mostly distributed in tropical to temperate seas and they introduced several seas as an invasive species. The meat of the pufferfish is consumes mostly as sashimi especially in the Fareast countries. However, if the pufferfish is not processed properly, it poses a threat to consumers due to tetrodotoxin they contain. For this reason, several researchers were studied on developing toxin determination methods. With the development of studies in this field, it has paved the way to get benefits from tetrodotoxin. Nowadays, scientists has started to get benefits from this severe toxin with using as medicine for treatment of several diseases. In this review, studies related to usages of tetrodotoxin in pharmaceutical industry were examined. Besides, we evaluated to future of the tetrodotoxin in pharmaceutical industry as an alternative medicine.

Keywords


Pufferfish, tetrodotoxin, MSFD, medicine, invasive species, analgesic.

References


  1. Acar C, Ishizaki S, Nagashima Y (2017) Toxicity of the Lessepsian pufferfish Lagocephalus sceleratus from eastern Mediterranean coasts of Turkey and species identification by rapid PCR amplification. Eur Food Res Technol 243:49–57. doi: 10.1007/s00217-016-2721-1
  2. Aydın M (2011) Growth, reproduction and diet of pufferfish (Lagocephalus sceleratus Gmelin, 1789) from Turkey’s Mediterranean Sea coast. Turkish J Fish Aquat Sci 11:596–576. doi: 10.4194/1303-2712-v11
  3. Bagal SK, Chapman ML, Marron BE, Prime R, Storer RI, Swain NA (2014) Recent progress in sodium channel modulators for pain. Bioorganic Med Chem Lett 24:3690–3699. doi: 10.1016/j.bmcl.2014.06.038
  4. Bane V, Lehane M, Dikshit M, O'Riordan A, Furey A (2014) Tetrodotoxin: Chemistry, toxicity, source, distribution and detection. Toxins (Basel) 6:693–755. doi: 10.3390/toxins6020693
  5. Berde CB, Athiraman U, Yahalom B, Zurakowski D, Corfas G, Bognet C (2011) Tetrodotoxin-bupivacaine-epinephrine combinations for prolonged local anesthesia. Mar Drugs 9:2717–2728. doi: 10.3390/md9122717
  6. Bilecenoğlu M, Kaya M, Cihangir B, Çiçek E (2014) An updated checklist of the marine fishes of Turkey. Turkish J Zool 38:901–929. doi: 10.3906/zoo-1405-60
  7. Buchwald HD, Durham L, Fischer HG, Harada R, Mosher HS, Kao CY, Fuhrman FA (1964) Identity of tarichatoxin and tetrodotoxin. Science (80) 143:474–475.
  8. Chau R, Kalaitzis JA, Neilan BA (2011) On the origins and biosynthesis of tetrodotoxin. Aquat Toxicol 104:61–72. doi: 10.1016/j.aquatox.2011.04.001
  9. Çinar ME, Bilecenoglu M, Ozturk B, Katagan T, Aysel V (2005) Alien species on the coasts of Turkey. Mediterr 6:119–146. doi: 10.12681/mms.187
  10. Diaz JH, Hu C (2009) Risks and benefits of seafood consumption. Trop Med Health 37:79–95. doi: 10.1016/j.amepre.2006.01.003
  11. Dib-Hajj SD, Geha P, Waxman SG (2017) Sodium channels in pain disorders: pathophysiology and prospects for treatment. Pain 158:97–107. doi: 10.1097/j.pain.0000000000000854
  12. European Commission (2017) EU consumer habits regarding fishery and aquaculture products - Special Eurobarometer 450. Directorate-General for Maritime Affairs and Fisheries
  13. FAO (2017a) FAO global capture production database updated to 2015 Summary information. In: Fish. Aquac. Dep. http://www.fao.org/3/a-br186e.pdf.
  14. FAO (2017b) An overview of recently published global aquaculture statistics. http://www.fao.org/3/a-bs235e.pdf. Accessed 10 Feb 2017
  15. Farrag M, El-Haweet A, Akel E-S, Moustafa M (2016) Occurrence of puffer fishes (Tetraodontidae) in the eastern Mediterranean, Egyptian coast - filling in the gap. BioInvasions Rec 5:47–54. doi: 10.3391/bir.2016.5.1.09
  16. Fouda FM (2005) Anti-tumor activity of tetrodotoxin extracted from the Masked Puffer fish. Egypt J Biol 7:1–13.
  17. Froese R, Pauly D (2017) FishBase, version (10/2017).
  18. Garud MS, Oza MJ, Gaikwad AB, Kulkarni YA (2017) Chapter 8 – natural remedies for treatment of cancer pain. Nutr Modul Pain Aging Popul 101–106. doi: https://doi.org/10.1016/B978-0-12-805186-3.00008-4
  19. Hagen NA, Cantin L, Constant J, Haller T, Blaise G, Ong-Lam M, Du Souich P, Korz W, Lapointe B (2017) Tetrodotoxin for moderate to severe cancer-related pain: a multicentre, randomized, double-blind, placebo-controlled, parallel-design trial. Pain Res Manag 1–7. doi: 10.1155/2017/7212713
  20. Hagen NA, Lapointe B, Ong-Lam M, Dubuc B, Walde D, Gagnon B, Love R, Goel R, Hawley P, Ngoc AH, du Souich P (2011) A multicentre open-label safety and efficacy study of tetrodotoxin for cancer pain. Curr Oncol 18:109–116. doi: 10.3747/co.v18i3.732
  21. Hajeb P, Mei HC, Noordin WN, Mahyudin NA (2012) Make the deadly yellow puffer fish a safe food to eat. J Food, Agric Environ 10:72–77.
  22. Itoi S, Yoshikawa S, Asahina K, Suzuki M, Ishizuka K, Takimoto N, Mitsuoka R, Yokoyama N, Detake A, Takayanagi C, Eguchi M, Tatsuno R, Kawane M, Kokubo S, Takanashi S, Miura A, Suitoh K, Takatani T, Arakawa O, Sakakura Y, Sugita H (2014) Larval pufferfish protected by maternal tetrodotoxin. Toxicon 78:35–40. doi: 10.1016/j.toxicon.2013.11.003
  23. Jensen TS (2017) Selective sodium channel blockers in trigeminal neuralgia. Lancet Neurol 16:255–256. doi: 10.1016/S1474-4422(17)30017-0
  24. Kao CY (1966) Tetrodotoxin, saxitoxin and their significance in the study of excitation phenomena. Pharmacol Rev 18:998–1048.
  25. Kasapidis P, Peristeraki P, Tserpes G, Magoulas A (2007) First record of the Lessepsian migrant Lagocephalus sceleratus (Gmelin 1789) (Osteichthyes: Tetraodontidae) in the Cretan Sea (Aegean, Greece). Aquat Invasions 2:71–73. doi: 10.3391/ai.2007.2.1.9
  26. Katikou P, Georgantelis D, Sinouris N, Petsi A, Fotaras T (2009) First report on toxicity assessment of the Lessepsian migrant pufferfish Lagocephalus sceleratus (Gmelin, 1789) from European waters (Aegean Sea, Greece). Toxicon 54:50–55. doi: 10.1016/j.toxicon.2009.03.012
  27. Kheifets J, Rozhavsky B, Girsh Solomonovich Z, Marianna R, Soroksky A (2012) Severe tetrodotoxin poisoning after consumption of Lagocephalus sceleratus (Pufferfish, Fugu) fished in Mediterranean Sea, treated with cholinesterase inhibitor. Case Reports Crit Care 2012:1–3. doi: 10.1155/2012/782507
  28. Kohane DS, J Y, Lu TN, Langer R, Strichartz GR, Berde CB (1998) A re-examination of tetrodotoxin for prolonged duration local anesthesia. Anesthesiology 98:119–131. doi: 10.1167/8.5.1.
  29. Kohane DS, Smith SE, Louis DN, Colombo G, Ghoroghchian P, Hunfeld NGM, Berde CB, Langer R (2003) Prolonged duration local anesthesia from tetrodotoxin-enhanced local anesthetic microspheres. Pain 104:415–421. doi: 10.1016/S0304-3959(03)00049-6
  30. Kosker AR, Özogul F, Durmus M, Ucar Y, Ayas D, Regenstein JM, Özogul Y (2016) Tetrodotoxin levels in pufferfish (Lagocephalus sceleratus) caught in the Northeastern Mediterranean Sea. Food Chem 210:332–337. doi: 10.1016/j.foodchem.2016.04.122
  31. Law R, Hanke G, Angelidis M, Batty J, Bignert A, Dachs J, Davies I, Denga Y, Duffek A, Herut B, Hylland K, Lepom P, Leonards P, Mehtonen J, Piha H, Roose P, Tronczynski J, Velikova V, Vethaak D (2010) Marine Strategy Framework Directive, Contaminants and Pollution Effects. Luxembourg
  32. Lihua Y, Li Z, Keqin X (1999) The study on the analgesia effect of tetrodotoxin.
  33. Lyu YS, Park SK, Chung K, Chung JM (2000) Low dose of tetrodotoxin reduces neuropathic pain behaviors in an animal model. Brain Res 871:98–103. doi: 10.1016/S0006-8993(00)02451-3
  34. Marcil J, Walczak JS, Guindon J, Ngoc AH, Lu S, Beaulieu P (2006) Antinociceptive effects of tetrodotoxin (TTX) in rodents. Br J Anaesth 96:761–768. doi: 10.1093/bja/ael096
  35. Moczydlowski EG (2013) The molecular mystique of tetrodotoxin. Toxicon 63:165–183. doi: 10.1016/j.toxicon.2012.11.026
  36. Neuman-Lee LA, Brodie ED, Hansen T, Brodie ED, French SS (2016) Comparing the natural and anthropogenic sodium channel blockers tetrodotoxin and indoxacarb in garter snakes. J Exp Zool Part A Ecol Genet Physiol 325:255–264. doi: 10.1002/jez.2012
  37. Ono T, Hayashida M, Tezuka A, Hayakawa H, Ohno Y (2013) Antagonist effects of tetrodotoxin on aconitine-induced cardiac Toxicity. J Nippon Med Sch 80:350–361. doi: 10.1272/jnms.80.350
  38. Panão I, Carrascosa C, Jaber JR, Raposo A (2016) Puffer fish and its consumption: To eat or not to eat? Food Rev Int 32:305–322. doi: 10.1080/87559129.2015.1075213
  39. Salas MM, McIntyre MK, Petz LN, Korz W, Wong D, Clifford JL. (2015) Tetrodotoxin suppresses thermal hyperalgesia and mechanical allodynia in a rat full thickness thermal injury pain model. Neurosci Lett 607:108–113. doi: 10.1016/j.neulet.2015.09.031
  40. Schwartz DM, Duncan KG, Fields HL, Jones MR (1998) Tetrodotoxin: Anesthetic activity in the de-epithelialized cornea. Graefe’s Arch Clin Exp Ophthalmol 236:790–794. doi: 10.1007/s004170050160
  41. Shi J, Liu TT, Wang X, et al (2009) Tetrodotoxin reduces cue-induced drug craving and anxiety in abstinent heroin addicts. Pharmacol Biochem Behav 92:603–607. doi: 10.1016/j.pbb.2009.02.013
  42. Swartenbroux F, Albajedo B, Angelidis M, Aulne M, Bartkevics V, Besada V, Bignert A, Bitterhof A, Hallikainen A, Hoogenboom R, Jorhem L, Jud M, Law R, Cederberg DL, McGovern E, Miniero R, Schneider R, Velikova V, Verstraete F, Vinas L, Vlad S (2010) Marine Strategy Framework Directive, Contaminants in Fish and Other Seafood. Luxembourg
  43. Tanaka SN (2008) Consuming the “oriental other,” constructing the cosmopolitan Canadian: reinterpreting Japanese culinary culture in Toronto’s Japanese restaurants. Queen’s University, Kingston, Ontario-Canada
  44. Toledo G, Hanifin C, Geffeney S, Brodie ED (2016) Convergent evolution of tetrodotoxin-resistant sodium channels in predators and prey. Curr Top Membr 78:87–113. doi: 10.1016/bs.ctm.2016.07.006
  45. Turan C (2010) Status and trend of Lessepsian species in marine waters of Turkey. Nicosia-Greece
  46. Williams BL (2010) Behavioral and chemical ecology of marine organisms with respect to tetrodotoxin. Mar Drugs 8:381–398. doi: 10.3390/md8030381
  47. Zakharov A, Vitale C, Kilinc E, Koroleva K, Fayuk D, Shelukhina I, Naumenko N, Skorinkin A, Khazipov R, Giniatullin R (2015) Hunting for origins of migraine pain: cluster analysis of spontaneous and capsaicin-induced firing in meningeal trigeminal nerve fibers. Front Cell Neurosci 9:1–14. doi: 10.3389/fncel.2015.00287
  48. Zhou ZS, Zhao ZQ (2000) Ketamine blockage of both tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels of rat dorsal root ganglion neurons. Brain Res Bull 52:427–33.

Full Text: PDF  |  PRES